What type of study is this?

This is a 16 S rRNA gene sequencing study (also classified as: metabolomic analyses, Principal Coordinate Analysis, LEfSe analysis, pathway enrichment analysis).

September 10, 2025Scientific ReportsOpen Access

Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes

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Authors

YMYasser MorsyUniversity of Zurich NSNesma S. ShafieMisr University for Science and Technology MMMohamed MostafaMisr University for Science and Technology

Discussion

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Implication

Analysis reveals significant differences in gut microbiota and metabolic pathways in diabetic individuals, indicating potential therapeutic targets.

Key Points

Diabetes is associated with significant alterations in gut microbiome composition and function, affecting metabolic pathways.
Microbial diversity was higher in the diabetic group, with increased Bacteroidaceae and Lachnospiraceae, suggesting impacts on metabolic regulation.
Metabolomic analyses indicated disruptions in fatty acid metabolism and glucose homeostasis linked to gut microbiota changes.
Pathway enrichment analysis identified key metabolic alterations that could serve as biomarkers for diabetic treatments.

Cite This Study

Morsy et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce6754b1d3bfb60f570e https://doi.org/10.1038/s41598-025-09328-w

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Implication

Analysis reveals significant differences in gut microbiota and metabolic pathways in diabetic individuals, indicating potential therapeutic targets.

Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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