Drimane sesquiterpenoids from cultures of the basidiomycete Panellus pusillus

In the quest for novel compounds with potent activities against human infectious diseases from fungi in Thailand, cultures of the basidiomycete Panellus pusillus strain TBRC-BCC 43793 were chemically investigated. A new drimane sesquiterpenoid, 1β-hydroxypereniporin A (1), together with a known drimane, 6β-hydroxy-isodrimenin, was isolated using silica gel column chromatography and preparative High Performance Liquid Chromatography (HPLC). Its structure was elucidated on the basis of the spectroscopic method. The isolated compounds were inactive in the antiplasmodial, antimycobacterial, and antibacterial activity assays.