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September 10, 2025Nature CommunicationsOpen Access

Noncanonical terpene cyclases for the biosynthesis of diterpenoids regulating chlamydospore formation in plant-associated Trichoderma

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Authors

MYMinjie YangKunming Institute of BotanyDLDesen LiKunming Institute of BotanyHDHai DengUniversity of Aberdeen

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Overview

Identification of unique terpene cyclases regulating diterpenoids and chlamydospore formation in fungi, suggesting evolutionary significance.

Key Points

  • TriDTCs, a new family of terpene cyclases, are involved in synthesizing key diterpenes, enhancing fungal survival.
  • Functional studies indicate TriDTCs regulate chlamydospore formation, impacting Trichoderma's biocontrol capabilities.
  • Phylogenetic analysis reveals TriDTCs have a narrow distribution across three genera, showing functional specificity in Trichoderma.
  • This research expands knowledge of terpene cyclase diversity and opens avenues for drug discovery involving these diterpenoids.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d01a54b1d3bfb60f6212https://doi.org/10.1038/s41467-025-63055-4
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Also Consider

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