What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

September 10, 2025Infectious Diseases and TherapyOpen Access

Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Systematic Review and Meta-Analysis

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Authors

KLKristina LindsleyIQVIA (United Kingdom)MBMargaret BurroughsAbbVie (United States)CHCándido Hernández-LópezGilead Sciences (Spain)

Discussion

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Implication

Systematic review finds no increased risk of hepatocellular carcinoma recurrence with direct-acting antivirals, suggesting positive outcomes for chronic hepatitis C treatment.

Key Points

No increased risk of hepatocellular carcinoma recurrence was observed with DAA therapy compared to interferon-based treatment.
Meta-analysis included 41 cohort studies with 10,563 total participants, confirming consistent results across different follow-up periods.
Data synthesis showed similar low recurrence rates for DAA therapy when compared to no antiviral treatment at all time points analyzed.
The findings support the positive benefit-risk profile of direct-acting antivirals for patients with chronic hepatitis C.

Cite This Study

Lindsley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d01a54b1d3bfb60f62e7 https://doi.org/10.1007/s40121-025-01180-9

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Implication

Systematic review finds no increased risk of hepatocellular carcinoma recurrence with direct-acting antivirals, suggesting positive outcomes for chronic hepatitis C treatment.

Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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