Observational analysis reveals exercise enhances neurotrophic factors in Parkinson's disease, indicating irisin may be a key target.
Exercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.
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Chen et al. (2025) studied this question.
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