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September 10, 2025npj Science of FoodOpen Access

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism

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Authors

JJJing JiWenzhou Hospital of Traditional Chinese MedicineZAZ.X. AnInstitute of Soil and Water ConservationAKAman KhanIndian Institute of Technology Bhilai

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Implication

Probiotic GR-5 markedly reduces uric acid levels in hyperuricemia, suggesting roles for gut microbiota and inflammation.

Key Points

  • GR-5 treatment reduced serum uric acid levels by about 52.17%, indicating its effectiveness in managing hyperuricemia.
  • The probiotic improved gut microbiota metabolism and restored intestinal barrier functions through increased tight junction proteins.
  • Inhibiting the NLRP3 inflammatory pathway highlights GR-5's potential to mitigate tissue inflammatory damage in hyperuricemia.
  • GR-5 colonization led to a rise in Lactobacillus abundance, suggesting enhanced metabolism of purines and other components.

Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/68c1d02354b1d3bfb60f6562https://doi.org/10.1038/s41538-025-00556-y
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