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September 10, 2025npj Systems Biology and ApplicationsOpen Access

Classification of first embryonic division stages of multiple Caenorhabditis species by deep learning

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Authors

DKDhruv KhatriPNPrachi NegiCAChaitanya A. Athale

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Overview

Using deep learning, CNNs accurately classify cell division stages in Caenorhabditis, highlighting asymmetric division mechanisms.

Key Points

  • The classification pipeline achieved over 91% accuracy in identifying distinct embryonic division stages.
  • Activation vectors from the networks correlate with features like pro-nuclei and spindle structures across multiple species.
  • Deep convolutional neural networks were trained to classify cell stages using DIC microscopy of various nematode embryos.
  • Classification success is contingent on conserved morphological features across comparable species in DIC imagery.

Cite This Study

Khatri et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03554b1d3bfb60f6d58https://doi.org/10.1038/s41540-025-00566-2
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