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September 10, 2025International Journal of NanomedicineOpen Access

Antimicrobial and Anti-Biofilm Activity of Dichlorophen-Functionalized Gold Nanoparticles Against Carbapenem-Resistant Enterobacteriaceae

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Authors

PHPanjie HuHCHuale ChenCQChangrui Qian

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Overview

This study demonstrates that gold nanoparticles functionalized with dichlorophen effectively combat carbapenem-resistant enterobacteriaceae, indicating strong potential as alternative treatments.

Key Points

  • DDM_Au NPs showed potent antibacterial activity against CRE, reducing bacterial load by 2-6 log10 CFU/mL.
  • The minimum inhibitory concentrations of DDM_Au NPs ranged from 4 to 16 μg/mL, demonstrating effective antimicrobial properties.
  • Mechanistic studies revealed that DDM_Au NPs disrupt bacterial membranes and elevate reactive oxygen species levels, enhancing antibacterial activity.
  • Dichlorophen-functionalized gold nanoparticles exhibited favorable biocompatibility and reduced inflammation in animal models, indicating their potential for clinical use.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03e54b1d3bfb60f7186https://doi.org/10.2147/ijn.s532807
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