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September 10, 2025AAPS PharmSciTechOpen Access

Voriconazole Loaded Spanlastics: Design, Formulation, Optimization, and Randomized Controlled Clinical Insights for Vulvovaginal Candidiasis Therapy

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Authors

NSNermin M. ShetaRSRehab Nabil ShammaRHRaghda R. S. Hussein

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Overview

Randomized controlled trial shows optimized voriconazole gel effectively manages vulvovaginal candidiasis, indicating potential for better treatment options.

Key Points

  • The optimized voriconazole-loaded spanlastic gel demonstrated a 1.3-fold enhancement in mucosal permeation compared to control, crucial for treatment efficacy.
  • The clinical study indicated similar efficacy and safety between the optimized gel and the market product, Canesten 2% clotrimazole, in managing vulvovaginal candidiasis.
  • Using a 3 2 factorial design, the formulation of voriconazole spanlastics achieved a high entrapment efficiency of 74.31%.
  • The findings suggest that the voriconazole-loaded system can be a potential alternative to conventional treatments, with no reported adverse effects.

Cite This Study

Sheta et al. (2025) studied this question.

synapsesocial.com/papers/68c1d21f54b1d3bfb60f73a2https://doi.org/10.1208/s12249-025-03205-5
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