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August 26, 2025European PsychiatryOpen Access

Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis

Michele De Prisco Cristiana Ţăpoi Vincenzo Oliva Robertas Strumila Christine Takami Lageborn Nicolaja Girone Monica Macellaro Juliana Braga de Salles Andrade Christian N. Schmitz Eduard Vieta Giovanna Fico

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Key Points

OCD comorbidity notably impacts clinical outcomes in individuals with bipolar disorder, complicating management.
The meta-analysis indicates a significant increase in symptom severity in bipolar disorder patients with OCD comorbidity.
The systematic review synthesizes data from multiple studies, emphasizing the importance of diagnosing OCD in bipolar patients.
Addressing OCD comorbidity may improve overall treatment efficacy and patient quality of life in bipolar disorder.

Implication

Systematic review and meta-analysis reveal significant effects of OCD comorbidity on bipolar disorder outcomes, suggesting treatment implications.

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Cite This Study

Prisco et al. (2025) studied this question.

synapsesocial.com/papers/68c1d22854b1d3bfb60f7981 https://doi.org/10.1192/j.eurpsy.2025.10087

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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