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September 10, 2025Frontiers in EndocrinologyOpen Access

Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis

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Authors

ZDZ. Y. DengSZSirui ZhangHZHaiyang Zhao

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Overview

Exploration reveals epimedium's potential and target mechanisms in undescended testis treatment.

Key Points

  • Analysis identified 27 bioactive compounds in epimedium, with quercetin and kaempferol showing promise.
  • Molecular docking demonstrated a strong binding affinity of Yinyanghuo B with the PARP1 protein at -7.2 kcal/mol.
  • Mendelian randomization confirmed the causal relationship of PARP1 reduction with lower undescended testis risk.
  • Functional enrichment highlighted key biological processes like stress response and DNA damage repair regulation.

Cite This Study

Deng et al. (2025) studied this question.

synapsesocial.com/papers/68c1d24654b1d3bfb60f8431https://doi.org/10.3389/fendo.2025.1642197
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