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September 10, 2025Clinical Practice and Cases in Emergency MedicineOpen Access

A Diagnostic Dilemma—Severe Hyperthermia and Rigidity in a Young Man with Polysubstance Use: A Case Report

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Authors

JOJohn T. O’BrienUniversity of Notre Dame MCMatthew CarveyMetroHealth

Discussion

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Implication

Case report highlights severe hyperthermia and altered mental status in a patient with polysubstance use, suggesting potential neuroleptic malignant syndrome.

Key Points

The case illustrates a patient with severe hyperthermia and rigidity, raising suspicion for neuroleptic malignant syndrome.
Initial lab results indicated metabolic acidosis and rhabdomyolysis, confirming significant physiological stress.
Management included rapid intubation and dantrolene, which effectively reduced rigidity and stabilized vital signs.
Highlighting the need for awareness of NMS in patients with complex histories and substance use for timely intervention.

Cite This Study

O’Brien et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f8690 https://doi.org/10.5811/cpcem.47071

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Implication

Case report highlights severe hyperthermia and altered mental status in a patient with polysubstance use, suggesting potential neuroleptic malignant syndrome.