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September 10, 2025World Journal of Surgical OncologyOpen Access

Impact of intraoperative margin optimization strategies compared to standard breast-conserving surgery on oncologic outcomes: a systematic review and meta-analysis of randomized and prospective trials

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Authors

WMWajahat MirzaRawalpindi Medical UniversityMMMuhammad MoazShifa Tameer-e-Millat UniversityMTMuhammad Sajeel Turab

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Overview

Systematic review demonstrates lower re-excision and positive margin rates in breast-conserving surgery, suggesting new standard practices.

Key Points

  • Intraoperative margin optimization reduced re-excision rates by 169 fewer per 1,000 patients, enhancing outcomes.
  • The study included six randomized controlled trials, providing a robust analysis of surgical and oncologic outcomes.
  • Positive margin rates decreased significantly, indicating the effectiveness of optimization strategies in surgical practice.
  • The findings suggest that adopting these strategies could improve surgical quality without negatively impacting local recurrence.

Cite This Study

Mirza et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f87cahttps://doi.org/10.1186/s12957-025-03959-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Margin status, re-excision, and completion mastectomy after oncoplastic versus conventional breast-conserving surgery for breast cancer: a systematic review and meta-analysis2026
  2. 2Intraoperative measurement of breast-conserving surgery margins: surgical application2026
  3. 3Re-Excision After Positive Margins in Breast-Conserving Surgery: Can a Risk-Based Strategy Avoid Unnecessary Surgery?2025 · 2 citations
  4. 4Risk Factors for Positive Resection Margins in Breast-Conserving Surgery for Breast Cancer—Retrospective Analysis2024 · 1 citations
  5. 5Oncoplastic Versus Standard Breast-conserving Surgery: Predictors of Re-excision, Complications, and Safety Outcomes2026 · 1 citations