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September 10, 2025Open Access

Goal-directed hippocampal theta sweeps during memory-guided navigation

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Large-scale recordings reveal how goal-directed sweeps encode trajectories in place cells, indicating coordination with prefrontal cortex activity.

Goal-directed theta sweeps predict upcoming trajectories in navigation, showing distinct patterns in place cell activity.
The study revealed that goal-directed sweeps were coordinated with prefrontal cortex activity and replayed during sharp-wave ripples.
Two types of place cell sequences were identified: left-right alternating sweeps and learning-dependent goal-directed sweeps.
A circuit mechanism involving CA1 cells and reduced feedback inhibition was described for encoding goal-directed navigation.

Tang et al. (2025) studied this question.

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Large-scale recordings reveal how goal-directed sweeps encode trajectories in place cells, indicating coordination with prefrontal cortex activity.