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September 10, 2025ACS Applied Materials & Interfaces

Bioengineered Chip Model for Magnetic-Nanoparticle-Driven Targeted Cancer Therapy

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Authors

DDDhruba DharDMDebolina MannaSLSampad Laha

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Overview

This research demonstrates a bioengineered chip that models the tumor microenvironment, enabling targeted drug delivery using magnetic drug carriers, facilitating novel therapy assessments.

Key Points

  • The bioengineered chip effectively replicates the tumor microenvironment, enhancing magnetic drug targeting accuracy.
  • A detailed analysis showcased the impact of magnetic fields and shear stress on drug retention by magnetic drug carriers during therapy.
  • High-resolution imaging and flow cytometry revealed significant activation of apoptotic pathways and reduced invasion markers.
  • This cost-effective and scalable platform is designed to simplify the preclinical screening of potential anticancer therapies.

Cite This Study

Dhar et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5ef54b1d3bfb60f8b97https://doi.org/10.1021/acsami.5c13763
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