This review highlights metabolic engineering strategies for sterol biosynthesis in saccharomyces cerevisiae, suggesting implications for agriculture and pharmaceuticals.
Sterols, crucial structural components of cellular membranes, exhibit essential biological functions and serve as key intermediates in the agricultural and pharmaceutical industries. Recent advances in synthetic biology have established Saccharomyces cerevisiae as a robust microbial chassis for sterol biosynthesis. Through strategic integration of heterologous pathways and systematic enhancement of metabolic flux, this eukaryotic platform has enabled de novo synthesis of diverse high-value steroids. This review systematically examines recent progress in metabolic engineering of S. cerevisiae for sterol biosynthesis and overproduction.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: