Observational analysis reveals Guilu Bushen Pill improves bone mineral density in ovariectomized rats, suggesting kidney health impacts bone strength.
Guilu Bushen Pill (GLBSW) is a traditional Chinese medicine formulation recognized for its kidney-nourishing effects. According to traditional Chinese medicine theory, kidney health is closely linked to bone strength. This study aims to investigate the effects of GLBSW on osteoblast differentiation using SaoS-2 cells, as well as its therapeutic potential in an ovariectomy-induced osteoporosis (OVX) rat model. In vitro results indicate that GLBSW significantly promotes the differentiation of SaoS-2 cells, while in vivo experiments demonstrate its effectiveness in alleviating osteoporosis in OVX rats by enhancing bone mineral density (BMD), improving both the quantity and quality of bone trabeculae, and maintaining calcium and phosphorus levels in bone. Metabolomic analysis of serum metabolites suggests that the therapeutic effects of GLBSW may be associated with the modulation of pyruvate and arachidonic acid metabolism. In conclusion, these findings underscore the potential of GLBSW in the treatment of osteoporosis through the regulation of bone formation and energy metabolism.
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Peng et al. (2025) studied this question.
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