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September 10, 2025Biotechnology Journal InternationalOpen Access

Prioritisation of Promising Therapeutic Targets in Plasmodium falciparum Using in Silico Multi Criteria Scoring

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Authors

MSMamadou SangaréCCCheickna CisséBDBakary N'tji Diallo

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Overview

Bioinformatics analysis reveals 16 potential therapeutic targets in Plasmodium falciparum, suggesting new pathways to combat drug resistance.

Key Points

  • The study identifies 16 potential therapeutic targets, including notable proteins like Adenylate kinase and PfCRT.
  • Five targets stand out for their roles in malaria invasion, replication, and immune evasion, critical for addressing drug resistance.
  • An in silico multi-criteria scoring system evaluated therapeutic targets, emphasizing essential criteria like druggability and lack of human orthologs.
  • Data was sourced from the WHO validated TDR Targets database, indicating a robust methodology for future drug discovery efforts.

Cite This Study

Sangaré et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5f754b1d3bfb60f8f8ehttps://doi.org/10.9734/bji/2025/v29i5790
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Also Consider

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  1. 1Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria2021 · 27 citations
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  4. 4In Silico Drug Discovery: Unveiling Potential Targets in Plasmodium falciparum through Molecular Docking Analysis2024
  5. 5High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>2024 · 4 citations