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This is a Literature Review study.

Neuroprotective Potential of Major Alkaloids from Nelumbo nucifera (Lotus): Mechanisms and Therapeutic Implications

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Review highlights neuroprotective effects of lotus alkaloids in neurodegenerative diseases, suggesting possible therapeutic roles.

Lotus-derived alkaloids exhibit neuroprotective effects, reducing oxidative stress-induced neuronal apoptosis.
Key alkaloids like neferine and nuciferine regulate calcium signaling and influence neurotransmitter systems.
These compounds support neurogenesis and reduce tau hyperphosphorylation, highlighting their therapeutic promise.
Further research is necessary to uncover their mechanisms and clinical applications in neurodegenerative diseases.

Zhao et al. (2025) studied this question.

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