MTCH2 in regulation of mitochondrial dynamics and metabolism: new insights and perspectives

Mitochondrial dynamics and metabolic plasticity bestow the adaptive flexibility to fit cellular stress and metabolic demands. Mitochondrial carrier homolog 2 (MTCH2) MTCH2 is initially recognized for its role in mediating apoptosis through the recruitment of tBID to mitochondria, triggering the outer membrane permeabilization. Recent studies reveal that MTCH2 is a regulator of mitochondrial dynamics, metabolism, protein insertion and the permeability transition pore (PTP). MTCH2's multifaceted roles in mitochondrial homeostasis, dynamics, biogenesis, metabolism and permeability transition provide a mechanistic explanation for its association with the wide range of phenotypes and disease states.