We disclose phosphine-mediated double annulation via a one-pot reaction for the construction of functionalized pyrrolofuranthridones. This one-pot protocol involves a Morita-Baylis-Hillman (MBH)-type/O-acylation/Wittig reaction sequence. Broad functional group tolerance is displayed, and a range of pyrrolofuranthridones are obtained in good to high yields. Furthermore, this methodology has been successfully extended to indoline N-alkynamides as substrates for the synthesis of dihydropyrrolofuranthridones in high yields.
No takes yet. Share an insight, caveat, or question.
Walunj et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: