This approach demonstrates divergent synthesis of pyrroles with excellent regioselectivity, suggesting implications for drug development.
Presented herein is a solvent-directed selective synthesis of 3-trifluoromethylated dihydropyrroles and pyrroles based on the anaerobic or aerobic reaction of trifluoromethyl-substituted dienamines via 6π-photocyclization. The work provides a robust protocol for the effective functionalization of dienamine derivatives, leading to the concise and selective assembly of pyrrole-related scaffolds bearing a pharmaceutically privileged CF₃ unit. This novel strategy features a photocatalyst-free process, divergent synthesis, formal hydroalkenylation, excellent regioselectivity, wide functional group tolerance, and operational convenience.
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Li et al. (2025) studied this question.
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