Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Journal of Clinical Medicine of KazakhstanOpen Access

Immunogenetic Landscape of Secondary Sjögren’s Syndrome in Systemic Sclerosis and Lupus Erythematosus: Insights from Kazakhstan

View Full Paper
Ask AI
Bookmark
Share

Authors

LZLina ZaripovaАBАbay BaigenzhinZZZhanna Zhabakova

Discussion

Loading...

Member takes

Overview

This analysis identifies genetic variants and immunological traits in patients with secondary sjögren’s syndrome, suggesting overlaps between lupus and scleroderma.

Key Points

  • Positive antinuclear factors were found in all SLE-sSS and 75% of SSc-sSS patients, indicating a strong autoimmune response.
  • Autoantibodies SS-A/Ro60 and SS-A/Ro52 more frequently appeared in both groups, while SS-B antibodies were less common, suggesting key biomarkers.
  • Whole-exome sequencing revealed likely pathogenic variants related to autoimmunity, highlighting the need for further genetic research.
  • Findings emphasize the necessity for larger studies due to limitations like small sample size and the cross-sectional nature of the research.

Cite This Study

Zaripova et al. (2025) studied this question.

synapsesocial.com/papers/68c1d60654b1d3bfb60f9878https://doi.org/10.23950/jcmk/16776
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genes, Antibodies, and Cytokines in Systemic Lupus Erythematosus: Update of Potential Biomarkers2024 · 4 citations
  2. 2Pathogenesis and treatment of Sjogren’s syndrome: Review and update2023 · 164 citations
  3. 3The CGGGG insertion/deletion polymorphism of the <i>IRF5</i> promoter is a strong risk factor for primary Sjögren's syndrome2009 · 107 citations
  4. 4Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis2015 · 40 citations
  5. 5Sjögren's syndrome and systemic lupus erythematosus: links and risks2019 · 92 citations