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September 10, 2025Veterinary ResearchOpen Access

N-glycosylation of the PEDV spike protein modulates viral replication and pathogenicity

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Authors

HZHuixin ZhuZFZhaoyang FengMSMeng Sun

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Overview

Reverse genetics reveal that spike protein modifications alter viral replication and pathogenicity in piglets, suggesting a pathway for vaccine development.

Key Points

  • Mutations disrupting N-glycosylation sites significantly reduced viral replication and plaque size.
  • In vivo assays showed minimal faecal shedding and no symptoms in piglets infected with attenuated strains.
  • The spike protein's glycosylation is critical for viral attachment and internalization, affecting PEDV infectivity.
  • Findings support the design of live attenuated vaccines using modified PEDV strains.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7e354b1d3bfb60f98fehttps://doi.org/10.1186/s13567-025-01606-9
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