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September 10, 2025FoodsOpen Access

Process Optimization for Polyphenol Extraction from Macroalgae Residues and Assessment of Their Compositions, Antioxidant Activities, and Glycosidase Inhibition

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Extraction process enhanced antioxidant activities and glycosidase inhibition of macroalgae residues, suggesting potential health applications.

Antioxidant activity was significantly higher in free polyphenols than bound polyphenols, indicating a more effective extraction strategy.
The optimal extraction conditions for bound polyphenols were identified as 50 °C with a solid–liquid ratio of 1:50 and 8 mol/L NaOH.
HPLC analysis showed distinct profiles with free polyphenols containing more diverse compounds compared to bound polyphenols.
Results demonstrated that free polyphenols exhibit a much stronger inhibition of glycosidase enzymes compared to their bound counterparts.

Luo et al. (2025) studied this question.

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Extraction process enhanced antioxidant activities and glycosidase inhibition of macroalgae residues, suggesting potential health applications.