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September 10, 2025MedicineOpen Access

Identification of a tumor microenvironment-related gene signature for predicting prognosis in patients with gastric cancer

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Observational analysis identifies gene signature associated with prognosis in gastric cancer, implying potential for improved risk stratification.

A TME-related gene signature can significantly predict the prognosis of patients with gastric cancer.
Four prognostic biomarkers were identified, with an area under the curve exceeding 0.6 across multiple datasets.
Mutation characteristics and immune cells were analyzed, revealing significant differences between high- and low-risk groups.
Key genes demonstrated differential expression validated by reverse transcription quantitative polymerase chain reaction and Western blot.

Li et al. (2025) studied this question.

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Observational analysis identifies gene signature associated with prognosis in gastric cancer, implying potential for improved risk stratification.