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September 10, 2025MedicineOpen Access

Prognosis of the transformation of myelodysplastic syndromes to acute myeloid leukemia: A retrospective study

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Authors

YWYufang WangFHFang‐Wen HuJKJinyong Ke

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Overview

Retrospective study reveals key prognostic factors and survival outcomes in MDS patients transforming to AML.

Key Points

  • Survival outcomes vary significantly, with ECOG score and IPSS score identified as critical prognostic factors.
  • Among patients transforming to AML, 39% had poor prognosis, with higher bone marrow blast percentages influencing outcomes.
  • Analysis utilized multivariate Cox regression to identify independent predictors of prognosis, emphasizing the need for targeted treatment strategies.
  • Complete remission notably improves survival rates, underscoring the importance of early intervention for high-risk patients.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa37bhttps://doi.org/10.1097/md.0000000000043783
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