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September 10, 2025Molecular PsychiatryOpen Access

Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks

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This review highlights how adolescent nicotine impacts neurocircuitry, leading to increased rates of psychiatric disorders.

Adolescent nicotine exposure leads to long-lasting neurocircuitry changes, increasing psychiatric risk in adulthood.
Evidence suggests that nicotine alters acetylcholine and dopamine systems, elevating vulnerability to disorders like schizophrenia.
Review of the mechanisms impacted by nicotine indicates disruptions to neuromodulator systems that govern emotional and cognitive processes.
Understanding these changes is crucial for developing targeted treatments for adolescent nicotine effects on mental health.

Reynolds et al. (2025) studied this question.

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