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September 10, 2025Open Access

A Multi-Trait Approach Improves Polygenic Risk Scores for Chronic Back Pain Across Population-Based and Clinically Ascertained Samples

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Authors

RORachael O. OsagieGFGoodarz Koli FarhoodMPMarc Parisien

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Overview

Application of multi-trait analysis shows improved polygenic risk scores in chronic back pain, suggesting clinical relevance and utility.

Key Points

  • The MTAG-PRS achieved improved clinical utility for chronic back pain with an AUC of 0.785 in clinician-ascertained cases.
  • External validation of the multi-trait polygenic risk score resulted in an AUC of 0.638, confirming its robustness across cohorts.
  • Polygenic risk scores improved through multi-trait analysis exhibited a better performance compared to single-trait scores.
  • Rigorous phenotyping alongside leveraging genetic pleiotropy advanced chronic back pain risk scores towards practical clinical applications.

Cite This Study

Osagie et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7fe54b1d3bfb60fa4a0https://doi.org/10.1101/2025.08.27.25334588
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