Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Bone Marrow TransplantationOpen Access

Conditioning intensity in myelodysplastic patients aged ≥ 50 years undergoing allogeneic hematopoietic cell transplantation (allo-HCT): a study on behalf of the chronic malignancies working party of the EBMT

View Full Paper
Ask AI
Bookmark
Share

Authors

NLNoureddine LoukiliLGLuuk GrasLKLinda Köster

Discussion

Loading...

Member takes

Overview

Retrospective study compares reduced intensity versus myeloablative conditioning in elderly MDS patients, indicating no significant outcome differences.

Key Points

  • There was no significant association between conditioning intensity and patient outcomes after allo-HCT.
  • Among 1393 patients, 75.5% received reduced intensity conditioning, with a median follow-up of 27.9 months.
  • Both univariate and multivariate analyses yielded no significant outcomes based on conditioning regimens used.
  • The findings align with a recent systematic review that suggests weak evidence for favoring one conditioning regimen over another.

Cite This Study

Loukili et al. (2025) studied this question.

synapsesocial.com/papers/68c1d97154b1d3bfb60fac5dhttps://doi.org/10.1038/s41409-025-02682-3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies2011 · 12,423 citations
  2. 2<b>mice</b>: Multivariate Imputation by Chained Equations in<i>R</i>2011 · 14,256 citations
  3. 3Comorbidity-Age Index: A Clinical Measure of Biologic Age Before Allogeneic Hematopoietic Cell Transplantation2014 · 427 citations
  4. 4Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia2020 · 165 citations
  5. 5Role of Age and Hematopoietic Cell Transplantation-Specific Comorbidity Index in Myelodysplastic Patients Undergoing an Allotransplant: A Retrospective Study from the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation2019 · 39 citations