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September 10, 2025New England Journal of Medicine

Multidomain Rehabilitation for Older Patients with Myocardial Infarction

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Authors

ETElisabetta TonetARAndrea RaisiSZSilvia Zagnoni

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Overview

Randomized trial shows lower cardiovascular death and hospitalization in older patients with myocardial infarction, suggesting rehabilitation benefits.

Key Points

  • Rehabilitation intervention decreased cardiovascular death or hospitalization by 33% in older patients.
  • Among 512 randomized patients, 12.6% experienced primary outcomes in the intervention group versus 20.6% in controls.
  • This multicenter randomized trial in Italy assessed older patients with myocardial infarction and impaired performance post-event.
  • Results highlight the need for multidomain rehabilitation in managing older patients after myocardial infarction.

Cite This Study

Tonet et al. (2025) studied this question.

synapsesocial.com/papers/68c1d97154b1d3bfb60fad4dhttps://doi.org/10.1056/nejmoa2502799
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Weekly Journal Scan: An integrated rehabilitation strategy after myocardial infarction in older patients with impaired physical performance2025
  2. 2Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial2026
  3. 3Physical performance and outcomes after myocardial infarction in older patients undergoing multidomain cardiac rehabilitation2026
  4. 4Recovery after Myocardial Infarction1991 · 70 citations
  5. 5Patient Education and Quality of Home-Based Rehabilitation in Patients Older Than 60 Years After Acute Myocardial Infarction2011 · 24 citations