Fluorescent sensor selectively detects Cu(II) in living human cells, suggesting new applications in bioimaging.
In this work, we present the rhodamine B hydrazide-based Cu(II) sensor EM21 that is excellently suited for selectively detecting Cu(II) under physiological conditions. We were able to demonstrate that it acquired cell permeability through n-alkylation at the hydrazide group and therefore capable to detect and compare Cu(II) concentrations sensitively in living human cells (cancer and normal cells).
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Körber et al. (2025) studied this question.
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