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September 10, 2025Open Access

The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.

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Authors

GLGerald Yu LiaoJKJenna KlugSDSherwin Dai

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Overview

Intermittent dosing of rapamycin and acarbose improves survival and behavior in house crickets, indicating potential in geroprotective research.

Key Points

  • Intermittent dosing of rapamycin significantly extends lifespan and preserves cognition in house crickets.
  • Key findings show rapamycin reduced mortality risk (HR = 0.42, P < 0.001) while acarbose increased risks in females.
  • Assessment involved behavioral tests on 274 crickets to evaluate effects of gerotherapeutic drugs on locomotion and survival.
  • Findings support the use of house crickets as a viable model for exploring geroprotective drugs.

Cite This Study

Liao et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98554b1d3bfb60fb456https://doi.org/10.1101/2025.08.25.671822
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension2024 · 14 citations
  2. 2A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket2026
  3. 3Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan2025 · 3 citations
  4. 4Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging2026
  5. 5Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats2016 · 29 citations