Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Clinical and Translational ScienceOpen Access

Recipient Versus Donor CYP3A4/5 Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant

View Full Paper
Ask AI
Bookmark
Share

Authors

EEEda EkenUniversity of FloridaSDSergio DuarteUniversity of FloridaIAIsabella Angeli‐PahimUniversity of Florida

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals recipient genotype impacts tacrolimus dosing in liver transplant patients, suggesting new dosing strategies.

Key Points

  • Recipient CYP3A5 genotype significantly influences tacrolimus dosing post-liver transplant.
  • 41% of liver transplant recipients had mismatched donor and recipient genotypes.
  • Dosing strategies based on recipient genotype yielded better outcomes than those based on donor genotype.
  • Two analyzed dosing methods achieved less than 2% prediction error using recipient genotype information.

Cite This Study

Eken et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98f54b1d3bfb60fb7dahttps://doi.org/10.1111/cts.70329
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B-222 Receptor-donor CYP3A5 and CYP3A4 genotype testing in liver transplant patients and its influence in tacrolimus blood levels: a retrospective study2024
  2. 2Impact of donor <i>CYP3A5</i> genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients2024
  3. 3Early CYP3A5 Genotype-Based Adjustment of Tacrolimus Dosage Reduces Risk of De Novo Donor-Specific HLA Antibodies and Rejection among CYP3A5-Expressing Renal Transplant Patients2024 · 4 citations
  4. 4Cohort Study to Determine the Impact of <i>CYP3A5</i> Genotype on Tacrolimus Dosing Requirements and Trough Concentrations in Heart Transplant Recipients2026
  5. 5CYP3A5 genotyping-guided dosing versus weight-based dosing in a multi-ethnic population of kidney transplant recipients2025