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September 10, 2025Alzheimer s & DementiaOpen Access

Association of plasma Alzheimer's disease biomarkers with cognitive decline in cognitively unimpaired individuals

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Authors

PCPetrice M. CogswellMayo ClinicHWHeather J. WisteDartmouth CollegeTTTerry M. TherneauMayo Clinic

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Implication

Cohort analysis reveals strong links between plasma Alzheimer’s disease biomarkers and cognitive decline, suggesting new predictive measures.

Key Points

  • Hazard ratios indicated higher risks of progression to mild cognitive impairment with specific plasma biomarkers.
  • In the MCSA and BioFINDER-2 studies, %p-tau217 and amyloid PET were significant predictors of cognitive decline.
  • Cox proportional hazards models were used to evaluate associations, adjusting for age, sex, and education.
  • Differences in biomarker performance were found between the two cohorts, highlighting the need for individualized assessments.

Cite This Study

Cogswell et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98f54b1d3bfb60fb858https://doi.org/10.1002/alz.70625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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