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Photocatalyzed Decarboxylative B–C Couplings for the Synthesis of Carboranyl Amino Acids and Peptides

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Visible-light-mediated B–C coupling synthesizes carboranyl peptides, enhancing tumor-targeting properties.

The successful synthesis of boron-vertex-substituted carboranylalanines was achieved with high yields and functional group tolerance.
Photogenerated boron vertex-centered radicals reacted with Dha residues to form peptide conjugates effectively in mild conditions.
This method's versatility allows incorporation of carboranyl units into biomolecules, including nucleic acid aptamers for better targeting.
Preliminary cellular studies show that aptamer–carborane–amino acid conjugates have efficient tumor cell uptake.

Zhou et al. (2025) studied this question.

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