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September 10, 2025International Journal of Stroke

Large-scale genetic study identifies shared genetic regions between cerebrovascular and neurodegenerative diseases

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Authors

AKAkhilesh Shailendra KhamkarIndian Institute of Science Education and Research, Bhopal SJS. K. JhaSRI International ABAjay Kumar BakhlaRajendra Institute of Medical Sciences

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Implication

Genome-wide analysis reveals shared genetic regions between cerebrovascular and neurodegenerative diseases, suggesting common pathways for multiple neurological disorders.

Key Points

The study identified 116 shared genetic loci linking cerebrovascular and neurodegenerative diseases.
Pleiotropic analysis resulted in the detection of 770 lead SNPs across different disease pairs with significant genetic correlations.
Genome-wide association studies provided data that revealed new causal genetic loci, including ERGIC1 between ALS and small vessel stroke.
Findings indicate a robust genetic risk score for stroke that is associated with neurodegenerative diseases across diverse ancestry groups.

Cite This Study

Khamkar et al. (2025) studied this question.

synapsesocial.com/papers/68c1d9a154b1d3bfb60fbb3c https://doi.org/10.1177/17474930251377513

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Implication

Genome-wide analysis reveals shared genetic regions between cerebrovascular and neurodegenerative diseases, suggesting common pathways for multiple neurological disorders.

Large-scale genetic study identifies shared genetic regions between cerebrovascular and neurodegenerative diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Large-scale genetic study identifies shared genetic regions between cerebrovascular and neurodegenerative diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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