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September 10, 2025Molecular PainOpen Access

EXPRESS: RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain

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Investigating how RIPK3 affects microglial polarization through the TLR4/MyD88 pathway in neuropathic pain, revealing potential treatment targets.

RIPK3 regulates microglial polarization, influencing neuropathic pain severity through the TLR4/MyD88 pathway.
After peripheral nerve injury, M1 microglial polarization was enhanced while M2 polarization was reduced.
The study utilized a chronic constriction injury (CCI) model in mice to explore microglial responses to nerve injury.
Findings suggest targeting RIPK3 and the TLR4/MyD88 pathway may provide new approaches for neuropathic pain management.

Sihan et al. (2025) studied this question.

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Investigating how RIPK3 affects microglial polarization through the TLR4/MyD88 pathway in neuropathic pain, revealing potential treatment targets.