Review summarizes synthesis of naphthoquinone-fused N-heterocycles via multicomponent reactions, indicating their medicinal potential.
The naphthoquinone-fused N-heterocycles are found in natural products and are important candidates in medicinal chemistry. The 1, 3-C, N-binucleophilic property of the 2-aminonaphthoquinone provides access for the synthesis of naphthoquinone-fused N-heterocycles. In recent years this property of 2-aminonaphthoquinone has been acknowledged greatly by the synthetic community for construction of variably dubstituted naphthoquinone-fused N-heterocycles. This review summarizes the important findings in this area during 2019-2024. Also the review highlights the gap and future perspective of the approach.
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Acharya et al. (2025) studied this question.
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