Hybrid composites based on calcium carbonate-phosphates and fibrin saturated with antibiotic

Hybrid composites based on calcium carbonate-phosphates and fibrin were obtained by wet precipitation in presence of citrated plasma (6–50 vol.%). Inorganic component of the composites represents amorphous calcium carbonatephosphates and amorphized carbonated hydroxyapatite (A-type) with a Ca/P ratio of 1.71. After 15 days of aging in the SBF model solution, the hybrid composites are enriched with biomimetic apatite (up to 8.8 wt.%) without changing of Ca/P ratio of 1.71. Fibrin macromolecules provide partial removal of CO 3 2– ions from the structure of hybrid composites and apatite-forming capacity in the model SBF solution. Hybrid composites absorb up to 92 % of ciprofloxacin from aqueous solutions; the sorption capacity reaches 0.126 mmol/g. During 10 days of soaking in physiological solution, the composites release up to 89 % of the antibiotic; rate constant of ciprofloxacin release for composites measures 0,021 mmol/(g ∙ h 0.25 ) versus 0,051 mmol/(g ∙ h 0.10 ) for calcium carbonate-phosphates