Interaction in the PAMPs – mucosal barrier – cytokines system in children with obesity

Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations between PAMPs and cytokines in obese children. Methods. The study included 198 children and adolescents aged 10 to 18 years with various degrees of alimentary-constitutional obesity and children without obesity. The concentrations of cytokines, trephoyl factors and PAMPs were determined by enzyme immunoassay method. Results. A statistically significant increase in the concentration of IL-17A (p=0.022) was revealed in obese children. When divided by gender, TNFα was significantly increased in obese boys (p=0.049) and fractalkine in girls (p=0.040). Conclusion. The interaction in the PAMPs-mucosal barrier-cytokine system in a group of obese children showed the strongest activation of the immune system in obese boys and the escape of inflammation beyond the intestinal barrier, which is enhanced in obesity due to the association, which has pro-inflammatory activity of flagellin with TFF3.