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Observational analysis shows increased liver index in young and old rats, suggesting potential for new liver therapies.
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism. Purpose of study. Study of proliferotropic effect of short peptides and polypeptide complex (PPC) in organotypic culture of liver from young and old rats. Methods. The adequate method of organotypic cultivation of liver tissue from rats of different age was used for rapid screening the biological activity of peptides. Results. It has been established that by the action of short peptides and PPC square index of liver explants was increased statistically significant both in young and old rats. Conclusion. The data obtained by the method of organotypic cultivation creates the basis for the development of new preparations, including gerontological, for treatment of liver patholog
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Рыжак et al. (2025) studied this question.
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