Oral Fluid Leptin Is Normal and Pathological

Introduction. Leptin is a representative of biologically active compounds produced by adipose tissue – adipokines. The traditional material for his research is blood. Saliva is a local secret of the glands of the initial part of the digestive tract, which has a high diagnostic potential. The aim: to analyze the literature data on the content of leptin and the clinical and diagnostic value of its study in oral fluid. Material and methods: the analysis of literary sources in the PubMed biomedical research search engine for 10 years by the combination of the words «salivary leptin» was performed. Results. 5 reviews and 29 original papers were found, providing data on age, sex and circadian characteristics of leptin content in mixed oral fluid. The independent clinical and diagnostic significance of the study of leptin in saliva in patients with systemic diseases such as metabolic syndrome and diabetes mellitus, as well as oral diseases (stomatitis, chronic periodontitis, tumor lesions of the oral cavity and others) has been revealed. Conclusion. The study of saliva leptin has an independent diagnostic potential both for diseases of the whole body and for diseases affecting mainly the organs of the oral cavity. The simplicity and non-invasiveness of oral fluid collection determines the prospects for further studies of leptin for clinical diagnostic diagnosis