Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones

Haijuan Qin; Xi Chen; Jing Liu; Mengfei Yang; Xia Zhao; Jie Kang; Kui Lu

doi:10.1039/d5ob01287b

January 1, 2025Organic & Biomolecular Chemistry

Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones

View Full Paper

Ask AI

Bookmark

Share

Key Points

The method successfully synthesizes ring-fused quinazolinones from unactivated alkenes via radical cyclization.
Under photoinduced conditions, the process operates without a photocatalyst or oxidant, simplifying synthesis.
The approach provides concise and mild reaction conditions, enhancing overall efficiency in producing target compounds.
This innovative technique represents a significant advancement in quinazolinone synthesis, potentially broadening its applications.

Implication

A novel radical cyclization method produces quinazolinones from unactivated alkenes, indicating mild conditions.

Abstract

A tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes under photoinduced conditions was developed to synthesize the ring-fused quinazolinones for the first time. The concise, mild and photocatalyst- and oxidant-free conditions, as...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/68c1dd9254b1d3bfb60fbee7 https://doi.org/10.1039/d5ob01287b

View Full Paper

Ask AI

Bookmark

Share

Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading