Hageman’s disease (hereditary factor XII deficiency). Review of literature, clinical observations

Hageman’s disease is a rare hereditary disorder of hemostasis, characterized by a deficiency of coagulation factor XII, accompanied by prolongation of blood clotting time (Lee–White) and activated partial thromboplastin time. These laboratory abnormalities are often thought to indicate an increased risk of bleeding, similar to hemophilia. This leads to the unnecessary use of transfusions and hemostatic therapy, since bleeding is rare in these patients. The article provides a review of the literature on Hageman’s disease and describes clinical cases of surgical treatment of children with factor XII deficiency.