Cu-Catalyzed Halogenation of Diaryliodonium Salts Containing Ortho-sidearm

A simple and efficient halogenation pathway has been delivered with various diaryliodonium salts, containing an ortho alcoholic sidearm, and CuCl or CuBr to produce chloroarenes and bromoarenes in para position only without any ortho aromatic isomer. The reaction conditions include temperature (60 oC), solvent (DMF) and reaction time (2 hours) were optimized in order to obtain high yields of products. All products were isolated and characterized via 1H-NMR and 13C-NMR. With further investigation, these methods could be the main entrance to prepare herbicides, insecticides and bactericides containing haloarenes in their structures.