Sensitivity and Resistance Patterns of Urinary Tract infections.

Objectives: To identify the most common bacteria causing urinary tract infections (UTI) and their sensitivity and resistance patterns for some antimicrobial agents. Methodology: A total of 773 cases from outpatients and inpatients attended Al-Wahda therapeutic and teaching hospital, Derna - Libya, clinically suspected as having UTI during 2021 and 2022, were examined for microbiological and pattern of antibiotic susceptibility by disc diffusion method. Results: By using direct smear microscopy and routine culture methods, different bacterial species were isolated from only 262 (33.9%), the remaining 511 (66.1%) of cases showed no bacterial growth. Bacteriological examination of urine showed that Escherichia coli was found in 106 (40.4%) of cases, Klebsiella in 59 (22.5%), Staph. epidermidis in 35 (13.3%), Staph. aureus in 32 (12.2%), Proteus spp. in 12 (4.5%), Pseudomonas in 8 (3%), Enterococci in 6 (2.3%), and Corynebacteria in 4 (1.5%) of cases. The antimicrobial sensitivity pattern in the treatment of UTIs indicated that the Ciprofloxacin shows (80.2% sensitivity) , Amoxicillin (70.2%), Nitrofurantoin (64.5%), and Ceftriaxone (61.8%). Meanwhile, for treating UTI produced by Enterococci, the antimicrobial drug of choice is Amoxicillin (70.2% sensitivity), Nalidixic acid (60.3% sensitivity), and Ampicillin (9.2% sensitivity), while for treating Pseudomonas spp, the drug of choice should be member of Fluoroquinolones group as Ciprofloxacin (80.2% sensitivity), and Sulfamethoxazole plus Trimethoprim (26.3% sensitivity). Conclusion: Urinary tract infection is a major cause of morbidity, especially in young children. Trends in choice of antibiotic treatment may change depending on locally determined resistances, common pathogens, and cost issues.