Surface Modification With 5-Aminosalicylic Acid Reduces Nanoparticle-Induced Oxidative Stress in Rat Serum

Titanium dioxide nanoparticles (TiO2 NPs) are emerging in many technologies, owing to their chemical stability, antibacterial and photocatalytic properties. However, they tend to accumulate in cells inducing oxidative stress, inflammation, and even apoptosis. The main goal of this study was to determine whether surface modification with 5-aminosalicylic acid (5-ASA) could reduce TiO2 NPs toxicity. Therefore, female adult Wistar rats were orally treated in a single dose with 2.5 ml 0.01 M HCl (nanoparticle solvent); 1000 mg/kg of bare, commercially available TiO2 or TiO2 NPs surface- modified with 5-ASA (5-ASA/TiO2 NPs). Oxidative stress parameters, including prooxidant/antioxidant balance (PAB), advanced oxidation protein products (AOPP), and lipid peroxidation (LPO) were measured in the serum. Treatment with 5-ASA/TiO2 NPs showed potential to diminish LPO, but not AOPP or PAB, compared to bare TiO2 NPs. It can be concluded that this modification only partially alleviates oxidative stress induced by TiO2 NPs, and the underlying mechanisms remain unclear.