Single CRP Measurement Vs Serial Measurements as a Predictive Value for Neonatal Sepsi

Neonatal Sepsis is a clinical manifestation of bacteraemia caused by microorganisms and their toxins. Diagnosis of neonatal sepsis is not easy because of unspecific signs & symptoms that may mimic other non-infectious conditions, This study is to to compare between single and serial CRP measurements; which may alter the diagnosis and management of neonates with possible sepsis. This prospective study was conducted in Neonatal department of Al-Wahda Teaching Hospital of Derna in the period from July 2020 to July 2021. This study was conducted involve 160 neonates admitted to the neonatal department with possible sepsis. The patients divided into two groups group A (n=80) for the single and group B (n=80) for the serial measurements. Serial CRP was more significant than single CRP as a marker for neonatal sepsis. Serial CRP levels are useful in the diagnostic evaluation of neonates with suspected infection. The sensitivity of a normal CRP at the initial evaluation is not sufficient to justify withholding antibiotic therapy. The positive predictive value of elevated CRP levels is low, especially for culture-proven early-onset infections.