The Activity of The Water Phase Extract of Anguilla marmorata Q. Gaimard from Lake Poso and Anguilla bicolor from Palu River in The Healing Process of Rattus norvegicus Cuts

Eel fish are very widely distributed in Indonesia, especially in the region of Central Sulawesi. Eel fish are widely cultivated since they are rich in high nutritional content such as vitamins and albumin. This research aimed to examine activities of the extract of water-phase eel fish (Anguilla marmorata and Anguilla bicolor) on the incised wound healing in white rats. The eel fish extract is used as a base for ointments, where the ointment base used was Adeps lanae. The treatments were divided into five test groups, namely the concentration of 5%, 10%, 15%, positive control, and negative control. The test animal used in this study was white rats, then on the back of the rat a 2 cm long incision was made, and ointment was applied twice a day for 21 days. The experimental animals used in this research were white male rats in which their backs were injured 2-cm long, and the ointment was applied twice a day for 21 days. The concentration that had the largest healing percentage was 15%. The measurement data were analyzed using One-Way ANOVA and continued with the Post Hoc Test (Duncan). The results showed that the eel fish Anguilla marmorata had the incised wound healing activity in the white rats where the highest healing concentration on the 21st day was seen in the 15% group with the percentage of 85.3%, and the lowest concentration was found in 5% group, with the percentage of 72.1%. Whereas for the eel fish Anguilla bicolor on the 21st day, the maximum healing obtained was with the 15% group (83.5%), and the minimum healing was found in the 5% group (66.5%). From the results of these percentages, it can be concluded that the extract of water-phase eel fish Anguilla marmorata and Anguilla bicolor has the incised wound healing activity in white rats, and the most effective concentration for the incised wound healing process of each fish for 21 days is the concentration of 15%, with the percentage of healing for the eel fish Anguilla marmorata is 85.3%, and the eel fish Anguilla bicolor is 83.5%.